Ion-Channel Antiepileptic Drugs: An Analytical Perspective on the Therapeutic Drug Monitoring (TDM) of Ezogabine, Lacosamide, and Zonisamide

The term seizures includes a wide array of different disorders with variable etiology, which currently represent one the most important classes neurological illnesses. As consequence, many antiepileptic drugs (AEDs) are available, exploiting activity mechanisms and providing levels performance in terms selectivity, safety, efficacy. AEDs among psychoactive frequently involved therapeutic drug monitoring (TDM) practices. Thus, plasma their metabolites monitored correlated to administered doses, efficacy, side effects, toxic effects. for any analytical endeavour, quality concentration data is only as good method allows. In this review, main techniques methods described, suitable TDM three belonging class ion channel agents: ezogabine (or retigabine), lacosamide, zonisamide. addition overview, provided, pertaining two use cases antiepileptics: drug–drug interactions neuroprotection studies. This review contains 146 references.